p53 Linear Diffusion along DNA Requires Its C Terminus
نویسندگان
چکیده
منابع مشابه
Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus
Upon cellular DNA damage, the p53 tumor suppressor protein transmits a signal to genes that control the cell cycle and apoptosis. One function of p53 that is important for its role in this pathway is its ability to function as a sequence-specific transcriptional activator. We demonstrate here that short single DNA strands can markedly stimulate the ability of human and murine p53 proteins to bi...
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REV1 is central to the DNA damage response of eukaryotes through an as yet poorly understood role in translesion synthesis. REV1 is a member of the Y-type DNA polymerase family and is capable of in vitro deoxycytidyl transferase activity opposite a range of damaged bases. However, non-catalytic roles for REV1 have been suggested by the Saccharomyces cerevisiae rev1-1 mutant, which carries a poi...
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متن کاملSliding of p53 along DNA can be modulated by its oligomeric state and by cross-talks between its constituent domains.
The p53 protein is a homotetrameric transcription factor whose monomers comprise several domains. Although its organization with and without DNA was elucidated recently, characterizing the p53-DNA complex at the atomic level remains challenging because of its many disordered regions. Here we use computational models to predict the wiring of the four chains composing p53 and study its sliding dy...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2004
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2004.09.032